Article
Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase.
Structure (London, England : 1993) - 5 Jul 2017
Padayatti Pius S, Leung Josephine H, Mahinthichaichan Paween, Tajkhorshid Emad, Ishchenko Andrii, Cherezov Vadim, Soltis S Michael, Jackson J Baz, Stout C David, Gennis Robert B, Zhang Qinghai
Abstract excerpt
The nicotinamide nucleotide transhydrogenase (TH) is an integral membrane enzyme that uses the proton-motive force to drive hydride transfer from NADH to NADP+ in bacteria and eukaryotes. Here we solved a 2.2-Å crystal structure of the TH transmembrane domain (Thermus thermophilus) at pH 6.5. This structure exhibits conformational changes of helix positions from a previous structure solved at pH 8.5, and reveals...
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