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Article

Unveiling the structural features of nonnative trimers of human superoxide dismutase 1.

Biochimica et biophysica acta. General subjects - 1 Mar 2020

Chao Wei-Chih, Lu Jyh-Feng, Wang Jinn-Shyan, Chiang Tzu-Hsuan, Lin Li-Ju, Lee Yao-Lin, Chou Pi-Tai

Abstract excerpt

BACKGROUND: Human SOD1 contains a single tryptophan residue (W32) which has been identified as a site of oxidative modification and a potentiator of aggregation involving in familial amyotrophic lateral sclerosis (fALS). In situ substitution of a tryptophan analog, 2,6-diazatryptophan ((2,6-aza)Trp) with its unique water-catalyzed proton transfer property, into proteins exhibits extraordinary sensitivity in the...

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PMID: 31734464
DOI: 10.1016/j.bbagen.2019.129483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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