Article
Determination of Protein Surface Hydration by Systematic Charge Mutations.
The journal of physical chemistry letters - 17 Dec 2015
Jia Menghui, Yang Jin, Qin Yangzhong, Wang Dihao, Pan Haifeng, Wang Lijuan, Xu Jianhua, Zhong Dongping
Abstract excerpt
Protein surface hydration is critical to its structural stability, flexibility, dynamics, and function. Recent observations of surface solvation on picosecond time scales have evoked debate on the origin of such relatively slow motions, from hydration water or protein charged side chains, especially with molecular dynamics simulations. Here we used a unique nuclease with a single tryptophan as a local probe and...
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