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Article

Loss of iron triggers PINK1/Parkin-independent mitophagy.

EMBO reports - 1 Dec 2013

Allen George F G, Toth Rachel, James John, Ganley Ian G

Abstract excerpt

In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. Using this assay, we identify iron chelators as a family of compounds that generate a strong mitophagy response. Iron chelation-induced mitophagy requires that cells undergo glycolysis, but does not require PINK1 stabilization or...

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Source

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Identifiers

PMID: 24176932
DOI: 10.1038/embor.2013.168
PMCID: PMC3981094

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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