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Article

Spatiotemporally controlled initiation of Parkin-mediated mitophagy within single cells.

Autophagy - 1 Oct 2011

Yang Jin-Yi, Yang Wei Yuan

Abstract excerpt

Mitophagy, the selective removal of mitochondria through the autophagic pathway, is involved in cellular mitochondria quality control. Dysfunctional mitochondria can be selectively eliminated through Parkin-mediated mitophagy. Parkin is a ubiquitin E3 ligase that selectively translocates onto impaired mitochondria to initiate mitophagy, and mutations in Parkin have been identified in autosomal recessive forms of...

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PMID: 22011618
DOI: 10.4161/auto.7.10.16626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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