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PINK1/Parkin mitophagy and neurodegeneration—what do we really know in vivo?

15 Feb 2017

Abstract excerpt

Mitochondria are essential organelles that provide cellular energy and buffer cytoplasmic calcium. At the same time they produce damaging reactive oxygen species and sequester pro-apoptotic factors. Hence, eukaryotes have evolved exquisite homeostatic processes that maintain mitochondrial integrity, or ultimately remove damaged organelles. This subject has garnered intense interest recently following the...

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PMID: 28213158
DOI: 10.1016/j.gde.2017.01.016

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