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Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization

14 Apr 2025

Abstract excerpt

Ferroptosis, a form of cell death instigated by iron-dependent lipid peroxidation reactions (LPO), is emerging as a promising therapeutic target for cancer. While the mechanisms governing LPO induction and suppression have gradually been unveiled, questions persist regarding the specific cellular location of LPO and the utilization of iron in driving cell death. A comprehensive understanding of these aspects...

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PMID: 40229298
DOI: 10.1038/s41467-025-58909-w

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