Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allele-specific regulation of DISC1 expression by miR-135b-5p.

European journal of human genetics : EJHG - 1 Jun 2014

Rossi Mari, Kilpinen Helena, Muona Mikko, Surakka Ida, Ingle Catherine, Lahtinen Jenni, Hennah William, Ripatti Samuli, Hovatta Iiris

Abstract excerpt

Disrupted-in-schizophrenia-1 (DISC1) gene has been established as a risk factor for various neuropsychiatric phenotypes. Both coding and regulatory variants in DISC1 have been identified and associated with these phenotypes in genetic studies. MicroRNAs (miRNAs) are important regulators of protein coding genes. Since the miRNA-mRNA target recognition mechanism is vulnerable to disruption by DNA polymorphisms, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Linear Models

Share to Luciferases

Share to MicroRNAs

Share to Nerve Tissue Proteins

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 24169524
DOI: 10.1038/ejhg.2013.246
PMCID: PMC4023220

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allele-specific regulation of DISC1 expression by miR-135b-5p.PMID 24169524Read ↗

Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.Semantic proximity Read ↗

Case-control association study of Disrupted-in-Schizophrenia-1 (DISC1) gene and schizophrenia in the Chinese population.Semantic proximity Read ↗

Disrupted-in-Schizophrenia-1.Semantic proximity Read ↗

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms.Semantic proximity Read ↗

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.Semantic proximity Read ↗

Association of the DISC1 and NRG1 genetic polymorphisms with schizophrenia in a Chinese population.Semantic proximity Read ↗

Association study of polymorphisms in the 5' upstream region of human DISC1 gene with schizophrenia.Semantic proximity Read ↗

Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han population.Semantic proximity Read ↗

Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development.Semantic proximity Read ↗

Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways.Semantic proximity Read ↗

Association analysis of the DISC1 gene with schizophrenia in the Japanese population and DISC1 immunoreactivity in the postmortem brain.Semantic proximity Read ↗

Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophreniaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.