Article
DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2009
Nakata Kenji, Lipska Barbara K, Hyde Thomas M, Ye Tianzhang, Newburn Erin N, Morita Yukitaka, Vakkalanka Radhakrishna, Barenboim Maxim, Sei Yoshitatsu, Weinberger Daniel R, Kleinman Joel E
Abstract excerpt
Disrupted-In-Schizophrenia-1 (DISC1) is a promising susceptibility gene for major mental illness, but the mechanism of the clinical association is unknown. We searched for DISC1 transcripts in adult and fetal human brain and tested whether their expression is altered in patients with schizophrenia and is associated with genetic variation in DISC1. Many alternatively spliced transcripts were identified, including...
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