Article
Expression and alteration of ras and p53 proteins in patients with lung carcinoma accompanied by idiopathic pulmonary fibrosis.
Cancer - 1 Aug 2002
Takahashi Toru, Munakata Mitsuru, Ohtsuka Yoshinori, Nisihara Hiroshi, Nasuhara Yasuyuki, Kamachi-Satoh Atsuko, Dosaka-Akita Hirotoshi, Homma Yukihiko, Kawakami Yoshikazu
Abstract excerpt
BACKGROUND: The ras oncogene and the p53 tumor suppressor gene play important roles in the carcinogenic process of lung carcinoma. The authors evaluated whether alterations of the ras and p53 proteins may contribute to the development of lung carcinoma in patients with idiopathic pulmonary fibrosis (IPF) and whether such alterations may explain the high incidence of lung carcinoma among patients with IPF....
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