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Article

Genetically modified neural stem cells for a local and sustained delivery of neuroprotective factors to the dystrophic mouse retina.

Stem cells translational medicine - 1 Dec 2013

Jung Gila, Sun Jing, Petrowitz Bettina, Riecken Kristoffer, Kruszewski Katharina, Jankowiak Wanda, Kunst Frank, Skevas Christos, Richard Gisbert, Fehse Boris, Bartsch Udo

Abstract excerpt

A continuous intraocular delivery of neurotrophic factors (NFs) is being explored as a strategy to rescue photoreceptor cells and visual functions in degenerative retinal disorders that are currently untreatable. To establish a cell-based intraocular delivery system for a sustained administration of NFs to the dystrophic mouse retina, we used a polycistronic lentiviral vector to genetically modify adherently...

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Share to Ciliary Neurotrophic Factor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24167317
DOI: 10.5966/sctm.2013-0013
PMCID: PMC3841080

Genes

CNTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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