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Article

HSV-1 vector-delivered FGF2 to the retina is neuroprotective but does not preserve functional responses.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2001

Spencer B, Agarwala S, Gentry L, Brandt C R

Abstract excerpt

Fibroblast growth factor 2 (bFGF, FGF2) exhibits mitogenic, angiogenic, wound healing, and neuroprotective properties. Infusion of FGF2 in vivo to treat neurodegenerative disorders in animal models results in increased survival of damaged neurons, but these effects are transient. To test the feasibility of HSV vector-delivered FGF2 for neuroprotection, we inserted the FGF2 gene under the control of the HCMV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11356079
DOI: 10.1006/mthe.2001.0307

Genes

FGF2
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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