Article

Optimization of AAV tools to target M&uumlller glial cells for retinal gene therapy

2026-04-11

Abstract excerpt

Reprogramming of M&uumlller glial (MG) cells into retinal neurons has the potential to treat vision loss by regenerating the retina. Development of efficient gene delivery systems to target the MG cells is critical. Adeno-associated virus (AAV) serotypes and promoter specificity are important factors that influence AAV transduction profile in the retina. However, studies that optimize these parameters to specifica...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 811ffa6a-6a66-59f2-9f5e-5ec4d3217631
DOI: 10.64898/2026.04.09.717359

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Optimization of AAV tools to target M&uumlller glial cells for retinal gene therapyDOI 10.64898/2026.04.09.717359Read

Optimization of AAV tools to target Muller glial cells for retinal gene therapySemantic proximity Read

Comparative Evaluation of Adeno-Associated Virus and Lentivirus Mediated Gene Transfer in Adult Rat Optic NerveSemantic proximity Read

Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates, and humansSemantic proximity Read

Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous SystemSemantic proximity Read

Adeno-associated virus vectors for retinal gene therapy in basic research and clinical studiesSemantic proximity Read

AAV mediated GDNF secretion from retinal glia slows down retinal degeneration in a rat model of retinitis pigmentosa.Semantic proximity Read

Neuritin1 <i>Cis</i> -Regulatory Elements Enable Gene Expression Preferentially in Retinal Ganglion CellsSemantic proximity Read

Retinal transduction profiling of diverse AAV serotypes via intravitreal injectionSemantic proximity Read

AAV-mediated expression of proneural factors stimulates neurogenesis from adult Müller glia <i>in vivo</i> .Semantic proximity Read

Conventional and Tropism-Modified High-Capacity Adenoviral Vectors Exhibit Similar Transduction Profiles in Human iPSC-Derived Retinal OrganoidsSemantic proximity Read

Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors.Semantic proximity Read

Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across speciesSemantic proximity Read