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Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo

10 Nov 2022

Abstract excerpt

Retinal ganglion cell (RGC) replacement therapy could restore vision in glaucoma and other optic neuropathies. We developed a rapid protocol for directly induced RGC (iRGC) differentiation from human stem cells, leveraging overexpression of NGN2. Neuronal morphology and neurite growth were observed within 1 week of induction; characteristic RGC-specific gene expression confirmed identity. Calcium imaging...

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PMID: 36368332
DOI: 10.1016/j.stemcr.2022.10.011

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