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Article

AAV mediated GDNF secretion from retinal glia slows down retinal degeneration in a rat model of retinitis pigmentosa.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Sept 2011

Dalkara Deniz, Kolstad Kathleen D, Guerin Karen I, Hoffmann Natalie V, Visel Meike, Klimczak Ryan R, Schaffer David V, Flannery John G

Abstract excerpt

Mutations in over 80 identified genes can induce apoptosis in photoreceptors, resulting in blindness with a prevalence of 1 in 3,000 individuals. This broad genetic heterogeneity of disease impacting a wide range of photoreceptor functions renders the design of gene-specific therapies for photoreceptor degeneration impractical and necessitates the development of mutation-independent treatments to slow...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21522134
DOI: 10.1038/mt.2011.62
PMCID: PMC3182364

Genes

GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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