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Article

Effects of Subretinal Gene Transfer at Different Time Points in a Mouse Model of Retinal Degeneration.

PloS one - 1 Jan 2016

Dai Xufeng, Zhang Hua, Han Juanjuan, He Ying, Zhang Yangyang, Qi Yan, Pang Ji-Jing

Abstract excerpt

Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is necessary for photoreceptors to generate an important lipid component of their membranes. The absence of LPCAT1 results in early and rapid rod and cone degeneration. Retinal degeneration 11 (rd11) mice carry a mutation in the Lpcat1 gene, and are an excellent model of early-onset rapid retinal degeneration (RD). To date, no reports have documented gene therapy...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27228218
DOI: 10.1371/journal.pone.0156542
PMCID: PMC4882044

Genes

LPCAT1
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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