Article
A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers.
Biomedical and environmental sciences : BES - 20 May 2024
Hu Wei Qiong, Zhou Wei Guang, Zhou Guang Wei, Liao Jia Xi, Shi Jia Xing, Xie FengYang, Li Shou Heng, Wang Yong, Feng Xian Hong, Gu Xiu Li, Chen Bi Feng
Abstract excerpt
Objective: The leptin receptor, encoded by the LEPR gene, is involved in tumorigenesis. A potential functional variant of LEPR, rs1137101 (Gln223Arg), has been extensively investigated for its contribution to the risk of digestive system (DS) cancers, but results remain conflicting rather than conclusive. Here, we performed a case-control study and subsequent meta-analysis to examine the association between...
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