Article
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children.
The Journal of clinical investigation - 1 Mar 2011
Duggal Priya, Guo Xiaoti, Haque Rashidul, Peterson Kristine M, Ricklefs Stacy, Mondal Dinesh, Alam Faisal, Noor Zannatun, Verkerke Hans P, Marie Chelsea, Leduc Charles A, Chua Streamson C, Myers Martin G, Leibel Rudolph L, Houpt Eric, Gilchrist Carol A, Sher Alan, Porcella Stephen F, Petri William A
Abstract excerpt
Malnutrition substantially increases susceptibility to Entamoeba histolytica in children. Leptin is a hormone produced by adipocytes that inhibits food intake, influences the immune system, and is suppressed in malnourished children. Therefore we hypothesized that diminished leptin function may increase susceptibility to E. histolytica infection. We prospectively observed a cohort of children, beginning at...
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