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Article

Leptin protects host cells from Entamoeba histolytica cytotoxicity by a STAT3-dependent mechanism.

Infection and immunity - 1 May 2012

Marie Chelsea S, Verkerke Hans P, Paul Shom N, Mackey Aaron J, Petri William A

Abstract excerpt

The adipocytokine leptin links nutritional status to immune function. Leptin signaling protects from amebiasis, but the molecular mechanism is not understood. We developed an in vitro model of ameba-host cell interaction to test the hypothesis that leptin prevents ameba-induced apoptosis in host epithelial cells. We demonstrated that activation of mammalian leptin signaling increased cellular resistance to amebic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22331430
DOI: 10.1128/IAI.06140-11
PMCID: PMC3347425

Genes

STAT3
SOCS3
TRIB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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