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Article

Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions.

International journal of cancer - 1 Apr 2008

Slattery Martha L, Wolff Roger K, Herrick Jennifer, Caan Bette J, Potter John D

Abstract excerpt

Leptin may play an important role in colorectal cancer because of its role in energy balance, insulin and inflammation. We evaluated the LEP rs2167270 (19 G > A) and rs7799039 (-2548 G > A) polymorphisms and the leptin receptor, LEPR rs6588147 (located in intron 2), polymorphism with risk of developing colon cancer in a study of 1,567 cases and 1,965 controls. We evaluated the effects of the polymorphisms with...

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Source

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Identifiers

PMID: 18059035
DOI: 10.1002/ijc.23135
PMCID: PMC2430084

Genes

LEP
LEPR
IGF1
IRS2
VDR
IGFBP3
IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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