Article
Strategies for developing prediction models from genome-wide association studies.
Genetic epidemiology - 1 Dec 2013
Wu Jincao, Pfeiffer Ruth M, Gail Mitchell H
Abstract excerpt
Genome-wide association studies (GWASs) have identified hundreds of single nucleotide polymorphisms (SNPs) associated with complex human diseases. However, risk prediction models based on them have limited discriminatory accuracy. It has been suggested that including many such SNPs can improve predictive performance. Here, we studied various aspects of model building to improve discriminatory accuracy, as...
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