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Article

Pitfalls of predicting complex traits from SNPs.

Nature reviews. Genetics - 1 Jul 2013

Wray Naomi R, Yang Jian, Hayes Ben J, Price Alkes L, Goddard Michael E, Visscher Peter M

Abstract excerpt

The success of genome-wide association studies (GWASs) has led to increasing interest in making predictions of complex trait phenotypes, including disease, from genotype data. Rigorous assessment of the value of predictors is crucial before implementation. Here we discuss some of the limitations and pitfalls of prediction analysis and show how naive implementations can lead to severe bias and misinterpretation of...

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Identifiers

PMID: 23774735
DOI: 10.1038/nrg3457
PMCID: PMC4096801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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