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Article

Improved risk prediction for Crohn's disease with a multi-locus approach.

Human molecular genetics - 15 Jun 2011

Kang Jia, Kugathasan Subra, Georges Michel, Zhao Hongyu, Cho Judy H

Abstract excerpt

Genome-wide association studies have identified numerous loci demonstrating genome-wide significant association with Crohn's disease. However, when many single nucleotide polymorphisms (SNPs) have weak-to-moderate disease risks, genetic risk prediction models based only on those markers that pass the most stringent statistical significance testing threshold may be suboptimal. Haplotype-based predictive models may...

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Identifiers

PMID: 21427131
DOI: 10.1093/hmg/ddr116
PMCID: PMC3298027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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