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Article

Oncogenetic mutations combined with MRD improve outcome prediction in pediatric T-cell acute lymphoblastic leukemia.

Blood - 18 Jan 2018

Petit Arnaud, Trinquand Amélie, Chevret Sylvie, Ballerini Paola, Cayuela Jean-Michel, Grardel Nathalie, Touzart Aurore, Brethon Benoit, Lapillonne Hélène, Schmitt Claudine, Thouvenin Sandrine, Michel Gerard, Preudhomme Claude, Soulier Jean, Landman-Parker Judith, Leverger Guy, Macintyre Elizabeth, Baruchel André, Asnafi Vahid

Abstract excerpt

Risk stratification in childhood T-cell acute lymphoblastic leukemia (T-ALL) is mainly based on minimal residual disease (MRD) quantification. Whether oncogenetic mutation profiles can improve the discrimination of MRD-defined risk categories was unknown. Two hundred and twenty FRALLE2000T-treated patients were tested retrospectively for NOTCH1/FBXW7/RAS and PTEN alterations. Patients with NOTCH1/FBXW7 (N/F)...

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Source

Identifiers

PMID: 29051182
DOI: 10.1182/blood-2017-04-778829

Genes

NOTCH1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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