Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: a GRAALL study.

doi:10.1182/blood-2011-02-334219

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Article

Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: a GRAALL study.

Blood - 10 Nov 2011

Ben Abdelali Raouf, Asnafi Vahid, Leguay Thibaut, Boissel Nicolas, Buzyn Agnès, Chevallier Patrice, Thomas Xavier, Lepretre Stephane, Huguet Françoise, Vey Norbert, Escoffre-Barbe Martine, Tavernier Emmanuelle, Reman Oumedaly, Fegueux Nathalie, Turlure Pascal, Rousselot Philippe, Cahn Jean-Yves, Lheritier Veronique, Chalandon Yves, Béné Marie-Christine, Macintyre Elizabeth, Dombret Hervé, Ifrah Norbert

Abstract excerpt

Despite recent progress in the understanding of acute lymphoblastic leukemia (T-ALL) oncogenesis, few markers are sufficiently frequent in large subgroups to allow their use in therapeutic stratification. Low ERG and BAALC expression (E/B(low)) and NOTCH1/FBXW7 (N/F) mutations have been proposed as powerful prognostic markers in large cohorts of adult T-ALL. We therefore compared the predictive prognostic value...

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Identifiers

PMID: 21835957
DOI: 10.1182/blood-2011-02-334219

Genes

BAALC
ERG
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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