Article
Adaptation of novel H7N9 influenza A virus to human receptors.
Scientific reports - 28 Oct 2013
Dortmans J C F M, Dekkers J, Wickramasinghe I N Ambepitiya, Verheije M H, Rottier P J M, van Kuppeveld F J M, de Vries E, de Haan C A M
Abstract excerpt
The emergence of the novel H7N9 influenza A virus (IAV) has caused global concerns about the ability of this virus to spread between humans. Analysis of the receptor-binding properties of this virus using a recombinant protein approach in combination with fetuin-binding, glycan array and human tissue-binding assays demonstrates increased binding of H7 to both α2-6 and α2-8 sialosides as well as reduced binding to...
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