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Article

Adaptation of influenza A (H7N9) virus in primary human airway epithelial cells.

Scientific reports - 12 Sept 2017

Huang Daniel Tsung-Ning, Lu Chun-Yi, Chi Ya-Hui, Li Wan-Ling, Chang Luan-Yin, Lai Mei-Ju, Chen Jin-Shing, Hsu Wen-Ming, Huang Li-Min

Abstract excerpt

Influenza A (H7N9) is an emerging zoonotic pathogen with pandemic potential. To understand its adaptation capability, we examined the genetic changes and cellular responses following serial infections of A (H7N9) in primary human airway epithelial cells (hAECs). After 35 serial passages, six amino acid mutations were found, i.e. HA (R54G, T160A, Q226L, H3 numbering), NA (K289R, or K292R for N2 numbering), NP...

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Identifiers

PMID: 28900138
DOI: 10.1038/s41598-017-10749-5
PMCID: PMC5595892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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