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Article

Preferential recognition of avian-like receptors in human influenza A H7N9 viruses.

Science (New York, N.Y.) - 6 Dec 2013

Xu Rui, de Vries Robert P, Zhu Xueyong, Nycholat Corwin M, McBride Ryan, Yu Wenli, Paulson James C, Wilson Ian A

Abstract excerpt

The 2013 outbreak of avian-origin H7N9 influenza in eastern China has raised concerns about its ability to transmit in the human population. The hemagglutinin glycoprotein of most human H7N9 viruses carries Leu(226), a residue linked to adaptation of H2N2 and H3N2 pandemic viruses to human receptors. However, glycan array analysis of the H7 hemagglutinin reveals negligible binding to humanlike α2-6-linked...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24311689
DOI: 10.1126/science.1243761
PMCID: PMC3954636

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