Article
Three mutations switch H7N9 influenza to human-type receptor specificity.
PLoS pathogens - 1 Jun 2017
de Vries Robert P, Peng Wenjie, Grant Oliver C, Thompson Andrew J, Zhu Xueyong, Bouwman Kim M, de la Pena Alba T Torrents, van Breemen Marielle J, Ambepitiya Wickramasinghe Iresha N, de Haan Cornelis A M, Yu Wenli, McBride Ryan, Sanders Rogier W, Woods Robert J, Verheije Monique H, Wilson Ian A, Paulson James C
Abstract excerpt
The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. The majority of human H7N9 isolates contained a hemagglutinin (HA) mutation (Q226L) that has previously been associated with a switch in receptor specificity from avian-type (NeuAcα2-3Gal) to human-type (NeuAcα2-6Gal), as documented for the avian progenitors of the 1957...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.