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Article

Dimeric peptides of the C-terminal region of CXCL14 function as CXCL12 inhibitors.

FEBS letters - 29 Nov 2013

Tanegashima Kosuke, Tsuji Kohei, Suzuki Kenji, Shigenaga Akira, Otaka Akira, Hara Takahiko

Abstract excerpt

We recently reported that CXCL14 binds to CXCR4 with high affinity and inhibits CXCL12-mediated chemotaxis. Here we found that the C-terminal 51-77 amino acid residues of CXCL14 are responsible for CXCR4 binding. A disulfide dimer peptide of CXCL14(51-77) bound to CXCR4 with comparable affinity to full length CXCL14, and exhibited CXCL12 inhibitor activity. CXCR4 was efficiently internalized upon binding of...

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Topics

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Share to Chemokine CXCL12
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Share to Dimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24161674
DOI: 10.1016/j.febslet.2013.10.017

Genes

CXCL14
CXCR4
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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