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Article

Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues.

The Journal of biological chemistry - 17 Aug 2012

Hoffmann Frauke, Müller Wiebke, Schütz Dagmar, Penfold Mark E, Wong Yung H, Schulz Stefan, Stumm Ralf

Abstract excerpt

CXCL12 signaling through G protein-coupled CXCR4 regulates cell migration during ontogenesis and disease states including cancer and inflammation. The second CXCL12-receptor CXCR7 modulates the CXCL12/CXCR4 pathway by acting as a CXCL12 scavenger and exerts G protein-independent functions. Given the distinct properties of CXCR4 and CXCR7, we hypothesized that the distinct C-terminal domains differently regulate...

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Share to Chemokine CXCL12
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22736769
DOI: 10.1074/jbc.M111.335679
PMCID: PMC3436560

Genes

CXCL12
CXCR4

Provenance

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