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Article

The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer

8 Dec 2020

Abstract excerpt

Chemokines are a family of small, secreted cytokines which regulate a variety of cell functions. The C-X-C motif chemokine ligand 12 (CXCL12) binds to C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7). The interaction of CXCL12 and its receptors subsequently induces downstream signaling pathways with broad effects on chemotaxis, cell proliferation, migration, and gene expression....

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Identifiers

PMID: 33363463
DOI: 10.3389/fphar.2020.574667

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