IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo.

doi:10.1182/blood-2011-06-362533

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Article

IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo.

Blood - 22 Dec 2011

Recher Mike, Berglund Lucinda J, Avery Danielle T, Cowan Morton J, Gennery Andrew R, Smart Joanne, Peake Jane, Wong Melanie, Pai Sung-Yun, Baxi Sachin, Walter Jolan E, Palendira Umaimainthan, Tangye Gillian A, Rice Michael, Brothers Shannon, Al-Herz Waleed, Oettgen Hans, Eibel Hermann, Puck Jennifer M, Cattaneo Federica, Ziegler John B, Giliani Silvia, Tangye Stuart G, Notarangelo Luigi D

Abstract excerpt

SCID resulting from mutations in IL2RG or JAK3 is characterized by lack of T and natural killer cells; B cells are present in normal number, but antibody responses are defective. Hematopoietic cell transplantation (HCT) is curative for SCID. However, B-cell dysfunction persists in a substantial proportion of patients. We hypothesized that impaired B-cell responses after HCT in IL2RG/JAK3 deficiency results from...

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PMID: 22039266
DOI: 10.1182/blood-2011-06-362533
PMCID: PMC3338166

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JAK3

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