Article
Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells.
EMBO reports - 1 Dec 2013
Peyronnet Rémi, Martins Joana R, Duprat Fabrice, Demolombe Sophie, Arhatte Malika, Jodar Martine, Tauc Michel, Duranton Christophe, Paulais Marc, Teulon Jacques, Honoré Eric, Patel Amanda
Abstract excerpt
Mechanical forces associated with fluid flow and/or circumferential stretch are sensed by renal epithelial cells and contribute to both adaptive or disease states. Non-selective stretch-activated ion channels (SACs), characterized by a lack of inactivation and a remarkably slow deactivation, are active at the basolateral side of renal proximal convoluted tubules. Knockdown of Piezo1 strongly reduces SAC activity...
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