Piezo activity levels need to be tightly regulated to maintain normal morphology and function in pericardial nephrocytes

Abstract excerpt

Abstract Due to their position on glomerular capillaries, podocytes are continuously counteracting biomechanical filtration forces. Most therapeutic interventions known to generally slow or prevent the progression of chronic kidney disease appear to lower these biomechanical forces on podocytes, highlighting the critical need to better understand podocyte mechano-signalling pathways. Here we investigated whether...

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