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Piezo1, F-Actin Remodeling, and Podocyte Survival and Regeneration

2 Apr 2025

Abstract excerpt

Key Points Piezo1 regulates perinuclear actin remodeling, and its loss induces nuclear envelope defects and accumulation of DNA damage. Piezo1 loss in podocytes leads to mitotic catastrophe. Podocyte-specific and podocyte progenitor–specific knockout of Piezo1 in mice result in severe albuminuria after adriamycin nephropathy. Background Podocytes and podocyte progenitors are interdependent components of the...

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PMID: 40172977
DOI: 10.1681/asn.0000000697

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