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Article

90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1

24 Oct 2013

Abstract excerpt

BACKGROUND: In response to viral infections, interferons induce the transcription of several hundred genes in mammalian cells. Specific antiviral functions, however, have only been attributed to a few of them. 90K/LGALS3BP has been reported to be an interferon-stimulated gene that is upregulated in individuals with cancer or HIV-1 infection. RESULTS: Here, we show that 90K expression dose-dependently decreased...

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PMID: 24156545
DOI: 10.1186/1742-4690-10-111

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