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Article

Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency

19 Aug 2022

Abstract excerpt

Abstract Background The generation of over 69 spliced HIV-1 mRNAs from one primary transcript by alternative RNA splicing emphasizes the central role that RNA processing plays in HIV-1 replication. Control is mediated in part through the action of host SR proteins whose activity is regulated by multiple SR kinases (CLK1-4, SRPKs). Methods Both shRNA depletion and small molecule inhibitors of host SR kinases were...

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PMID: 35986377
DOI: 10.1186/s12977-022-00605-4

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