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Article

NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2014

Wen Xi, Huang Xiaofeng, Mok Bobo Wing-Yee, Chen Yixin, Zheng Min, Lau Siu-Ying, Wang Pui, Song Wenjun, Jin Dong-Yan, Yuen Kwok-Yung, Chen Honglin

Abstract excerpt

NF90 was shown to exhibit broad antiviral activity against several viruses, but detailed mechanisms remain unclear. In this study, we examined the molecular basis for the inhibitory effect of NF90 on virus replication mediated through protein kinase (PKR)-associated translational regulation. We first verified the interaction between NF90 and PKR in mammalian cells and showed that NF90 interacts with PKR through...

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PMID: 24623135
DOI: 10.4049/jimmunol.1302813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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