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Article

[Role of LNK gene mutation in pathogenesis of myeloproliferative neoplasms-review].

Zhongguo shi yan xue ye xue za zhi - 1 Oct 2013

Chen Yan, Wu Xue-Qiang, Han Chun-Sheng, Zhu Ping, Wei Jun-Yan

Abstract excerpt

Myeloproliferative neoplasms ( MPN ) is a class of clonal hematopoietic stem cell disease. Studies found that the JAK-STAT signaling pathway is closely related to the pathogenesis of MPN. The lymphocyte-specific adaptor protein (LNK) gene negatively regulates Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling and may play an important role in the pathogenesis of MPN. Especially in...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24156456
DOI: 10.7534/j.issn.1009-2137.2013.05.045

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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