Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Polymorphisms in LNK Gene Correlated to the Clinical Type of Myeloproliferative Neoplasms.

PloS one - 1 Jan 2016

Chen Yan, Fang Fang, Hu Yang, Liu Qian, Bu Dingfang, Tan Mei, Wu Liusong, Zhu Ping

Abstract excerpt

OBJECTIVE: LNK is an adapter protein negatively regulating the JAK/STAT cell signaling pathway. In this study, we observed the correlation between variation in LNK gene and the clinical type of myeloproliferative neoplasms (MPN). METHODS: A total of 285 MPN cases were recruited, including essential thrombocythemia (ET) 154 cases, polycythemia vera (PV) 76 cases, primary myelofibrosis (PMF) 19 cases, and chronic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Flanking Region
Share to 5' Flanking Region
Share to Fusion Proteins, bcr-abl

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Polycythemia Vera

Share to Primary Myelofibrosis

Share to Thrombocythemia, Essential

Source

Open in PubMed Open full text

Identifiers

PMID: 27111338
DOI: 10.1371/journal.pone.0154183
PMCID: PMC4844169

Genes

JAK2
ABL1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Polymorphisms in LNK Gene Correlated to the Clinical Type of Myeloproliferative Neoplasms.PMID 27111338Read ↗

[Role of LNK gene mutation in pathogenesis of myeloproliferative neoplasms-review].Semantic proximity Read ↗

[Variation of LNK Gene in Chronic Myeloid Leukemia].Semantic proximity Read ↗

Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms.Semantic proximity Read ↗

Genetics of the myeloproliferative neoplasms.Semantic proximity Read ↗

The role of LNK/SH2B3 genetic alterations in myeloproliferative neoplasms and other hematological disorders.Semantic proximity Read ↗

LNK can also be mutated outside PH and SH2 domains in myeloproliferative neoplasms with and without V617FJAK2 mutation.Semantic proximity Read ↗

LNK mutations and myeloproliferative disorders.Semantic proximity Read ↗

[Variation and Clinical Significance of LNK Gene in Essential Thrombocytosis].Semantic proximity Read ↗

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasmsSemantic proximity Read ↗

The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Semantic proximity Read ↗

In silico analysis of Missense Variants in Human MPL Gene Associated with Essential ThrombocythemiaSemantic proximity Read ↗

Possible new LNK mutations in myeloproliferative neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.