Article
Longitudinal analysis of HIV-1 coreceptor tropism by single and triplicate HIV-1 RNA and DNA sequencing in patients undergoing successful first-line antiretroviral therapy.
The Journal of antimicrobial chemotherapy - 1 Mar 2014
Meini Genny, Rossetti Barbara, Bianco Claudia, Ceccherini-Silberstein Francesca, Di Giambenedetto Simona, Sighinolfi Laura, Monno Laura, Castagna Antonella, Rozera Gabriella, D'Arminio Monforte Antonella, Zazzi Maurizio, De Luca Andrea
Abstract excerpt
OBJECTIVES: Maraviroc has been shown to be effective in patients harbouring CCR5-tropic HIV-1. While this CCR5 antagonist has initially been used in salvage therapy, its excellent safety profile makes it ideal for antiretroviral treatment simplification strategies in patients with suppressed plasma viraemia. The aim of this study was to compare HIV-1 tropism as detected in baseline plasma RNA and peripheral blood...
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