Article
Effects of sequence alterations on results from genotypic tropism testing.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Apr 2015
Pironti Alejandro, Sierra Saleta, Kaiser Rolf, Lengauer Thomas, Pfeifer Nico
Abstract excerpt
BACKGROUND: geno2pheno[coreceptor] is a bioinformatic method for genotypic tropism determination (GTD) which has been extensively validated. OBJECTIVES: GTD can be affected by sequencing/base-calling variability and unreliable representation of minority populations in Sanger bulk sequencing. This study aims at quantifying the robustness of geno2pheno[coreceptor] with respect to these issues. GTD with a single...
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