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Article

A weighted U statistic for association analyses considering genetic heterogeneity.

Statistics in medicine - 20 Jul 2016

Wei Changshuai, Elston Robert C, Lu Qing

Abstract excerpt

Converging evidence suggests that common complex diseases with the same or similar clinical manifestations could have different underlying genetic etiologies. While current research interests have shifted toward uncovering rare variants and structural variations predisposing to human diseases, the impact of heterogeneity in genetic studies of complex diseases has been largely overlooked. Most of the existing...

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PMID: 26833871
DOI: 10.1002/sim.6877
PMCID: PMC4899187

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