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Article

Genetic heterogeneity: Challenges, impacts, and methods through an associative lens.

Genetic epidemiology - 1 Dec 2022

Woodward Alexa A, Urbanowicz Ryan J, Naj Adam C, Moore Jason H

Abstract excerpt

Genetic heterogeneity describes the occurrence of the same or similar phenotypes through different genetic mechanisms in different individuals. Robustly characterizing and accounting for genetic heterogeneity is crucial to pursuing the goals of precision medicine, for discovering novel disease biomarkers, and for identifying targets for treatments. Failure to account for genetic heterogeneity may lead to missed...

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PMID: 35924480
DOI: 10.1002/gepi.22497
PMCID: PMC9669229

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