Article
Interplay of LRRK2 with chaperone-mediated autophagy.
Nature neuroscience - 1 Apr 2013
Orenstein Samantha J, Kuo Sheng-Han, Tasset Inmaculada, Arias Esperanza, Koga Hiroshi, Fernandez-Carasa Irene, Cortes Etty, Honig Lawrence S, Dauer William, Consiglio Antonella, Raya Angel, Sulzer David, Cuervo Ana Maria
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease. We found LRRK2 to be degraded in lysosomes by chaperone-mediated autophagy (CMA), whereas the most common pathogenic mutant form of LRRK2, G2019S, was poorly degraded by this pathway. In contrast to the behavior of typical CMA substrates, lysosomal binding of both wild-type and several pathogenic mutant...
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