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Advances in autophagy for Parkinson’s disease pathogenesis and treatment

18 Mar 2025

Abstract excerpt

Autophagy is a cellular process essential for maintaining neuronal homeostasis by degrading and recycling damaged organelles and proteins. Impairments in canonical autophagy pathways, such as macroautophagy, chaperone-mediated autophagy (CMA), and mitophagy, are linked to Parkinson's disease (PD) pathogenesis, contributing to α-synuclein aggregation and dopaminergic neuronal loss. Moreover, the recent discovery...

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PMID: 41536634
DOI: 10.20517/and.2024.33

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