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Article

Distinctive origin and spread route of pyrimethamine-resistant Plasmodium falciparum in southern China.

Antimicrobial agents and chemotherapy - 1 Jan 2014

Zhang Yilong, Yan He, Wei Guiying, Han Shitong, Huang Yufu, Zhang Qingfeng, Pan Weiqing

Abstract excerpt

Southeast Asia (the Thailand-Cambodia border) has been considered the primal epicenter for most antimalarial drug resistance; however, numerous molecular epidemiological studies have successively reported multiple independent origins of sulfadoxine-pyrimethamine (SP) resistance-associated Plasmodium falciparum dhfr (pfdhfr) and pfdhps alleles in other areas. To better understand the origin and evolutionary...

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Identifiers

PMID: 24145550
DOI: 10.1128/AAC.00972-13
PMCID: PMC3910728

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