Article
Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study.
The Lancet. Infectious diseases - 1 Mar 2018
Amato Roberto, Pearson Richard D, Almagro-Garcia Jacob, Amaratunga Chanaki, Lim Pharath, Suon Seila, Sreng Sokunthea, Drury Eleanor, Stalker Jim, Miotto Olivo, Fairhurst Rick M, Kwiatkowski Dominic P
Abstract excerpt
BACKGROUND: Antimalarial resistance is rapidly spreading across parts of southeast Asia where dihydroartemisinin-piperaquine is used as first-line treatment for Plasmodium falciparum malaria. The first published reports about resistance to antimalarial drugs came from western Cambodia in 2013. Here, we analyse genetic changes in the P falciparum population of western Cambodia in the 6 years before those reports....
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