Article
Origin and evolution of sulfadoxine resistant Plasmodium falciparum.
PLoS pathogens - 26 Mar 2010
Vinayak Sumiti, Alam Md Tauqeer, Mixson-Hayden Tonya, McCollum Andrea M, Sem Rithy, Shah Naman K, Lim Pharath, Muth Sinuon, Rogers William O, Fandeur Thierry, Barnwell John W, Escalante Ananias A, Wongsrichanalai Chansuda, Ariey Frederick, Meshnick Steven R, Udhayakumar Venkatachalam
Abstract excerpt
The Thailand-Cambodia border is the epicenter for drug-resistant falciparum malaria. Previous studies have shown that chloroquine (CQ) and pyrimethamine resistance originated in this region and eventually spread to other Asian countries and Africa. However, there is a dearth in understanding the origin and evolution of dhps alleles associated with sulfadoxine resistance. The present study was designed to reveal...
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